Researchers at their Institute of Biomedical Sciences at Tokushima University conducted experiments in mice to demonstrate how the inflammatory process in tissues contributes to a set of excess weight. According to scientists, the whole thing is in the protein TLR9, which is responsible for innate immunity.
Scientists have found that the isolation of DNA from adipocytes (subspecies of fat cells) leads to inflammation, which in turn reduces the sensitivity to insulin, which lowers blood glucose levels.
Scientists planted laboratory rodents on a diet and for three months gave them food with a high fat content. In this case, the mice were found to have a high activity of TLR9 protein in adipose tissue and a significant number of free DNA.
Researchers learned that the synthesis of this protein produces macrophages, the main function of which is to destroy toxins. When scientists suppressed the synthesis of protein, this led to a decrease in the number of macrophages, suppressed the inflammatory process and increased susceptibility to insulin.
Scientists stressed that the lack of excess animal fat coming from food leads to a natural decrease in the number of macrophages and, accordingly, to a high sensitivity to insulin, so that man can maintain the optimal weight.
The research report was published in the publication "Science Advances".
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